#1 Alcohol exerts its damaging effects by several different cellular pathways. Ethanol has a direct effect on membrane fluidity, leading to loss of membrane regulatory control and cell swelling. Another pathway involves the production of excess acetaldehyde from the metabolism of alcohol. Acetaldehyde exerts toxic effects on the hepatocyte and is responsible for a more severe lesion. During alcohol metabolism NADPH is formed, leading to an elevated redox potential favoring accumulation of hepatic triglycerides.

#1 I am unable to find orlistat info on the link provided by you.

#1 Thanks for the link. Excellent resource.